个人简介

吴晶霞，女，国家级人才计划（2022）获得者，2005年毕业于南京大学生命科学研究院，生物技术专业（生化药学强化班），获理学学士学位；2012年毕业于中国科学院上海生命科学研究院，生物化学与分子生物学专业，获理学博士学位；2012至2014年在美国耶鲁大学医学院心血管研究中心从事博士后研究；2016至2023年在德国癌症研究中心从事博士后研究，2023年入职合肥综合性国家科学中心大健康研究院。主要研究糖脂代谢信号通路及糖脂代谢对抗病毒、抗肿瘤免疫反应的调控机制。现发表学术论文22篇，其中第一作者身份论文发表在Immunity, Science Translational Medicine, Science Advances等期刊。

研究兴趣及方向

1. 探索糖脂代谢及糖脂代谢相关疾病对抗病毒、抗肿瘤免疫反应的影响，尤其是对CD8+ T细胞分化和功能调控的影响

2. 阐明在抗病毒、抗肿瘤免疫反应中代谢分子对T细胞分化和功能调控的作用机制

3. 开发以代谢分子为靶点的增强T细胞抗病毒、抗肿瘤功能的小分子或蛋白药物

代表性工作

1. Wu J#, Ma S#, Sandhoff R#, Ming Y, Hotz-Wagenblatt A, Timmerman V, Bonello-Palot N, Schlotter-Weigel B, Auer-Grumbach M, Seeman P, Loscher WN, Reindl M, et al. Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8(+) T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity 2019;50:1218-31 e5. # co-first author.

2. Wu J, Weisshaar N, Hotz-Wagenblatt A, Madi A, Ma S, Mieg A, Hering M, Mohr K, Schlimbach T, Borgers H, Cui G. Skeletal muscle antagonizes antiviral CD8(+) T cell exhaustion. Science Advances 2020;6:eaba3458.

3. Hwangbo C#, Wu J#, Papangeli I, Adachi T, Sharma B, Park S, Zhao L, Ju H, Go GW, Cui G, Inayathullah M, Job JK, et al. Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelins glucose-lowering effects. Science Translational Medicine 2017;9. # co-first author.

4. Wu J, Madi A, Mieg A, Hotz-Wagenblatt A, Weisshaar N, Ma S, Mohr K, Schlimbach T, Hering M, Borgers H, Cui G. T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development. Cell Reports 2020;31:107484.

5. Wu J, Zhang F, Yan M, Wu D, Yu Q, Zhang Y, Zhou B, McBurney MW, Zhai Q. WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasis. Diabetes 2011;60:3197-207.

6. Wu J, Ma S, Hotz-Wagenblatt A, Angel P, Mohr K, Schlimbach T, Schmitt M, Cui G. Regulatory T cells sense effector T-cell activation through synchronized JunB expression. FEBS Letters 2019;593:1020-29.

7. Weisshaar N, Wu J, Ming Y, Madi A, Hotz-Wagenblatt A, Ma S, Mieg A, Hering M, Zettl F, Mohr K, Schlimbach T, Ten Bosch N, Hertel F, Müller L, Byren H, Wang M, Borgers H, Munz M, Schmitt L, van der Hoeven F, Kloz U, Carretero R, Schleußner N, Jackstadt R, Hofmann I, Cui G. Rgs16 promotes antitumor CD8(+) T cell exhaustion. Science Immunology 2022;7:eabh1873.

8. Madi A, Wu J, Ma S, Weisshaar N, Mieg A, Hering M, Ming Y, Zettl F, Mohr K, Ten Bosch N, Schlimbach T, Hertel F, Cui G. Regulatory T cell-derived interleukin-15 promotes the diversity of immunological memory. Eur J Immunol 2023;53:e2149400.

9. Mehrotra D, Wu J, Papangeli I, Chun HJ. Endothelium as a gatekeeper of fatty acid transport. Trends Endocrinol Metab 2014;25:99-106.

10. Cui G, Staron MM, Gray SM, Ho PC, Amezquita RA, Wu J, Kaech SM. IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity. Cell 2015;161:750-61.

11. Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ. Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circulation Research 2013;113:22-31.

12. Zhou B, Zhang Y, Zhang F, Xia Y, Liu J, Huang R, Wang Y, Hu Y, Wu J, Dai C, Wang H, Tu Y, Peng X, Wang Y, Zhai Q. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. Hepatology 2014;59:2196-206.

13. Madi A, Weisshaar N, Buettner M, Poschet G, Ma S, Wu J, Mieg A, Hering M, Ming Y, Mohr K, Ten Bosch N, Cui G. CD8 agonism functionally activates memory T cells and enhances antitumor immunity. Int J Cancer 2022;151:797-808.

14. Lamas-Murua M, Stolp B, Kaw S, Thoma J, Tsopoulidis N, Trautz B, Ambiel I, Reif T, Arora S, Imle A, Tibroni N, Wu J, Cui G, Stein J, Tanaka M, Lyck R, Fackler O. HIV-1 Nef Disrupts CD4(+) T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface. J Immunol 2018;201:2731-43.

15. Kim JD, Kang Y, Kim J, Papangeli I, Kang H, Wu J, Park H, Nadelmann E, Rockson SG, Chun HJ, Jin SW. Essential role of Apelin signaling during lymphatic development in zebrafish. Arterioscler Thromb Vasc Biol 2014;34:338-45.

16. Zhang Y, Zhou B, Deng B, Zhang F, Wu J, Wang Y, Le Y, Zhai Q. Amyloid-beta induces hepatic insulin resistance in vivo via JAK2. Diabetes 2013;62:1159-66.

17. Zhang Y, Zhou B, Zhang F, Wu J, Hu Y, Liu Y, Zhai Q. Amyloid-beta induces hepatic insulin resistance by activating JAK2/STAT3/SOCS-1 signaling pathway. Diabetes 2012;61:1434-43.

18. Zhou B, Li C, Qi W, Zhang Y, Zhang F, Wu J, Hu Y, Wu D, Liu Y, Yan T, Jing Q, Liu M, Zhai Q. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia 2012;55:2032-43.

19. Yan M, Wang Y, Hu Y, Feng Y, Dai C, Wu J, Wu D, Zhang F, Zhai Q. A high-throughput quantitative approach reveals more small RNA modifications in mouse liver and their correlation with diabetes. Anal Chem 2013;85:12173-81.

20. Liu Y, Zhou D, Zhang F, Tu Y, Xia Y, Wang H, Zhou B, Zhang Y, Wu J, Gao X, He Z, Zhai Q. Liver Patt1 deficiency protects male mice from age-associated but not high-fat diet-induced hepatic steatosis. J Lipid Res 2012;53:358-67.

21. Yu Q, Wang T, Zhou X, Wu J, Chen X, Liu Y, Wu D, Zhai Q. Wld(S) reduces paraquat-induced cytotoxicity via SIRT1 in non-neuronal cells by attenuating the depletion of NAD. PLoS One 2011;6:e21770.

22. Zhang F, Sun C, Wu J, He C, Ge X, Huang W, Zou Y, Chen X, Qi W, Zhai Q. Combretastatin A-4 activates AMP-activated protein kinase and improves glucose metabolism in db/db mice. Pharmacol Res 2008;57:318-23.

因课题组工作需要，诚聘优秀人才加盟。该招聘信息长期有效。

一、助理研究员、博士后（3名）

岗位任务：

在课题组长指导下开展研究工作，积极申请各种基金，协助组长进行团队建设，指导学生。

岗位要求：

1. 生物化学及分子生物学、免疫学、细胞生物学、基础医学等相关专业的博士学位或者即将取得博士学位；

2.对科研有强烈的好奇心和求知欲，有拼搏进取精神，工作认真负责，有较强的团队协作能力；

3.以第一作者身份在领域内主流期刊上发表过或即将发表研究论文，能够独立开展研究工作。

二、科研助理、实验技术员（3名）

岗位要求：

1. 具有生物化学及分子生物学、免疫学、细胞生物学、基础医学等相关专业的学士及以上学位，具有实验动物操作经验者优先；

2. 做事踏实靠谱，认真负责；

3. 独立或协助团队开展课题研究，管理和维护实验室日常工作。

三、待遇及福利

工资及福利待遇按合肥综合性国家科学中心大健康研究院有关规定执行，提供极具市场竞争力的薪酬和福利（包括奖励及假期等）,一人一议，支持个人长期发展，工作突出者可推荐深造机会。

四、应聘方式

有意者请将个人简历（包括学习经历、科研及工作经历、发表论文、实验技能等）和其他能证明个人能力的相关材料以电子版（应聘职位+姓名）的形式发送至：jingxia.wu@ihm.ac.cn。

合肥综合性国家科学中心大健康研究院2023年招聘公告